Belizentrin, a highly bioactive macrocycle from the dinoflagellate Prorocentrum belizeanum
| Autor: | David Cabrera-García, M. Teresa Fernández-Sánchez, José J. Fernández, José G. Napolitano, Antonello Novelli, Manuel Norte, Antonio Hernández Daranas, Humberto J. Domínguez |
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| Rok vydání: | 2014 |
| Předmět: |
Neurons
biology Molecular Structure Stereochemistry Chemistry Prorocentrum belizeanum Metabolite Lactams Macrocyclic Organic Chemistry Dinoflagellate Marine Biology Carbene compounds biology.organism_classification Belizentrin Biochemistry chemistry.chemical_compound Chemical structure Mathematical methods Dinoflagellida Physical and Theoretical Chemistry Macrocycles Molecular structure Nuclear Magnetic Resonance Biomolecular |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1523-7052 |
| Popis: | Belizentrin (1), a novel 25-membered polyketide-derived macrocycle, was isolated from cultures of the marine dinoflagellate Prorocentrum belizeanum. This metabolite is the first member of an unprecedented class of polyunsaturated and polyhydroxylated macrolactams. The structure of 1 was primarily determined by NMR and computational methods. Pharmacological assays with cerebellar cells showed that 1 produces important changes in neuronal network integrity at nanomolar concentrations. |
| Databáze: | OpenAIRE |
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