Development and in vitro/in vivo evaluation of etodolac controlled porosity osmotic pump tablets
| Autor: | Ahmed Abdelbary, Mina Ibrahim Tadros, Ahmed Adel Alaa-Eldin |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Osmosis Sodium Potassium Chemistry Pharmaceutical Drug Evaluation Preclinical Pharmaceutical Science chemistry.chemical_element Pilot Projects Polyethylene glycol Aquatic Science Intestinal absorption chemistry.chemical_compound Drug Discovery medicine Humans Etodolac Ecology Evolution Behavior and Systematics Chromatography Cross-Over Studies Ecology General Medicine Cellulose acetate chemistry Intestinal Absorption Drug delivery Mannitol Tablets Enteric-Coated Agronomy and Crop Science Porosity medicine.drug Research Article |
| Zdroj: | AAPS PharmSciTech. 12(2) |
| ISSN: | 1530-9932 |
| Popis: | The aim of the current work was the design and evaluation of etodolac controlled porosity osmotic pump (CPOP) tablets exhibiting zero-order release kinetics. Variables influencing the design of (1) core tablets viz., (a) osmogent type (sodium chloride, potassium chloride, mannitol, and fructose) and (b) drug/osmogent ratio (1:0.25, 1:0.50, and 1:0.75), and (2) CPOP tablets viz., (a) coating solution composition, (b) weight gain percentage (1–5%, w/w), and (c) pore former concentration (5%, 10%, and 20%, v/v), were investigated. Statistical analysis and kinetic modeling of drug release data were estimated. Fructose-containing core tablets showed significantly (P |
| Databáze: | OpenAIRE |
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