Maternal Immune Activation Causes Behavioral Impairments and Altered Cerebellar Cytokine and Synaptic Protein Expression
| Autor: | Gurudutt Pendyala, Anna Dunaevsky, Ming Li, Shinnyi Chou, Yoosun Jung, Elizabeth Spartz, Ragunathan Padmashri, Pierluca Coiro |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Chemokine Cerebellum Dendritic spine endocrine system diseases Offspring medicine.medical_treatment Hippocampus Mice Transgenic Nerve Tissue Proteins 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Animals Protein Precursors Pharmacology biology Psychiatry and Mental health 030104 developmental biology Cytokine medicine.anatomical_structure Receptors Glutamate Maternal Exposure Prenatal Exposure Delayed Effects Protein Biosynthesis Synapses biology.protein Cytokines Tumor necrosis factor alpha Original Article Female Psychopharmacology Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuropsychopharmacology |
| ISSN: | 1740-634X 0893-133X |
| Popis: | Emerging epidemiology studies indicate that maternal immune activation (MIA) resulting from inflammatory stimuli such as viral or bacterial infections during pregnancy serves as a risk factor for multiple neurodevelopmental disorders including autism spectrum disorders and schizophrenia. Although alterations in the cortex and hippocampus of MIA offspring have been described, less evidence exists on the impact on the cerebellum. Here, we report altered expression of cytokines and chemokines in the cerebellum of MIA offspring, including increase in the neuroinflammatory cytokine TNFα and its receptor TNFR1. We also report reduced expression of the synaptic organizing proteins cerebellin-1 and GluRδ2. These synaptic protein alterations are associated with a deficit in the ability of cerebellar neurons to form synapses and an increased number of dendritic spines that are not in contact with a presynaptic terminal. These impairments are likely contributing to the behavioral deficits in the MIA exposed offspring. |
| Databáze: | OpenAIRE |
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