Assessing Medication Adherence Barriers to Short-Term Oral Antibiotic Treatment in Primary Care—Development and Validation of a Self-Report Questionnaire (BIOTICA)
| Autor: | Melanie Haag, Isabelle Arnet, Kurt E. Hersberger |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis pharmaceutical care Psychological intervention Medication adherence Primary care Self report questionnaire Article 03 medical and health sciences 0302 clinical medicine Cronbach's alpha Surveys and Questionnaires medicine Humans patient-centred pharmaceutical care 030212 general & internal medicine Primary Health Care business.industry 030503 health policy & services Public Health Environmental and Occupational Health Construct validity Reproducibility of Results Focus group Anti-Bacterial Agents Pharmaceutical care responsibilities/roles in pharmaceutical care Family medicine medicines optimization medication adherence Medicine Female Self Report 0305 other medical science business |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 18 Issue 15 International Journal of Environmental Research and Public Health, Vol 18, Iss 7768, p 7768 (2021) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph18157768 |
| Popis: | Background: Pharmacists are increasingly involved in strategies to fight antimicrobial resistance by ensuring optimised antibiotic (AB) use, including adherence support. Successful adherence interventions should be tailored to patients’ barriers and validated instruments are needed. This study aimed to identify adherence barriers to AB treatment, develop a self-report questionnaire, and validate it in outpatients. Method: Adherence barriers were identified through a systematic literature search and focus group discussion. Unmodifiable and irrelevant barriers were excluded from further processing. A validation study assessed the questionnaire’s internal reliability and construct validity by comparing the questionnaire’s score with electronically monitored adherence data. Results: A 15-item questionnaire was created. Overall, 68 patients were included in the construct validation analysis (60.3% female). The mean consecutive taking adherence was 88% and the most frequently reported barriers were “worries about side-effects” (37%) and “having swallowing difficulties” (19%). Three items were excluded from the questionnaire, which was supported by an increase of Cronbach’s alpha (0.69 to 0.70). The 12-item version’s score correlated significantly with medication adherence rate (r = −0.34, p < 0.01). Conclusion: The self-report questionnaire is a reliable and valid tool to pre-emptively assess adherence barriers in outpatients prescribed ABs. In the future, appropriate adherence interventions can be matched to barriers and tested in a pilot intervention study. |
| Databáze: | OpenAIRE |
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