Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial
| Autor: | Katarzyna Wojtyniak, Andrea Horvath, Piotr Dziechciarz, Hania Szajewska |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Lactobacillus casei Placebo law.invention 03 medical and health sciences 0302 clinical medicine Lactobacillus rhamnosus Randomized controlled trial Double-Blind Method law Internal medicine medicine Humans 030212 general & internal medicine Intention-to-treat analysis biology business.industry Lacticaseibacillus rhamnosus biology.organism_classification medicine.disease Surgery Biological Therapy Lacticaseibacillus casei Relative risk Child Preschool Pediatrics Perinatology and Child Health Defecation Functional constipation 030211 gastroenterology & hepatology Female business Constipation |
| Zdroj: | The Journal of pediatrics. 184 |
| ISSN: | 1097-6833 |
| Popis: | To assess the effectiveness of Lactobacillus casei rhamnosus Lcr35 (Lcr35) in the management of functional constipation in children.A randomized, double-blind, placebo-controlled trial was conducted in 94 children aged5 years with functional constipation according to the Rome III criteria. Children were assigned to receive Lcr35 (8 × 10Eighty-one (86%) children completed the study. There was no significant difference in treatment success between the placebo and the Lcr35 group (28/40 vs 24/41, respectively; relative risk, 0.6, 95% CI 0.24-1.5, P = .4). There was a significant increase in the frequency of defecation from baseline to week 4 in both the placebo group (median [IQR] 2.0 [1.0, 2.0] to 6.0 [4.0, 9.0], P .001) and in the Lcr35 group (2.0 [1.0, 2.0] to 4.0 [3.0, 5.0], P .001), but the defecation frequency in the placebo group was significantly greater than that in the Lcr35 group at weeks 1, 2, 3, and 4.Lcr35 as a sole treatment was not more effective than placebo in the management of functional constipation in children5 years. This study adds to current recommendations that do not support the use of probiotics in the treatment of childhood constipation.ClinicalTrials.gov: NCT01985867. |
| Databáze: | OpenAIRE |
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