Pamidronate attenuates diastolic dysfunction induced by myocardial infarction associated with changes in geometric patterning
| Autor: | Bertha F. Polegato, Fernanda Chiuso-Minicucci, Bruna Paola Murino Rafacho, Elenize Jamas Pereira, Paula S. Azevedo, Sergio A. R. Paiva, Marina Politi Okoshi, Bruna Letícia Buzati Pereira, Marcos F. Minicucci, Luiz Henrique Congio, Nara Aline Costa, Katashi Okoshi, Renan Floret Turini Claro, Andréa Gonçalves, Leonardo A. M. Zornoff, Priscila P. Santos |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.medical_treatment Diastole Myocardial Infarction Pamidronate Body weight lcsh:Physiology Sarcoplasmic Reticulum Calcium-Transporting ATPases Sham group lcsh:Biochemistry Subcutaneous injection Internal medicine Ventricular remodeling medicine Animals lcsh:QD415-436 Calcium handling proteins Myocyte hypertrophy Myocardial infarction Rats Wistar Saline Tissue Inhibitor of Metalloproteinase-1 lcsh:QP1-981 Diphosphonates Ventricular Remodeling business.industry Myocardium Bisphosphonates medicine.disease Surgery Rats Matrix Metalloproteinase 9 Echocardiography Cardiology Matrix Metalloproteinase 2 business Cell Adhesion Molecules |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Cellular Physiology and Biochemistry, Vol 35, Iss 1, Pp 259-269 (2015) |
| Popis: | Made available in DSpace on 2015-10-21T13:08:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-01-01. Added 1 bitstream(s) on 2015-10-22T09:53:27Z : No. of bitstreams: 1 WOS000348048000024.pdf: 3141987 bytes, checksum: c7f7398f8ea48b5e5581e174fc423327 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background/Aims: The aim of this study was to evaluate the influence of pamidronate on ventricular remodeling after myocardial infarction. Methods: Male Wistar rats were assigned to four groups: a sham group, in which animals were submitted to simulated surgery and received weekly subcutaneous injection of saline (S group; n=14); a group in which animals received weekly subcutaneous injection of pamidronate (3 mg/kg of body weight) and were submitted to simulated surgery (SP group, n=14); a myocardial infarction group, in which animals were submitted to coronary artery ligation and received weekly subcutaneous injection of saline (MI group, n=13); and a myocardial infarction group with pamidronate treatment (MIP group, n=14). The rats were observed for three months. Results: Animals submitted to MI had left chamber enlargement and worse diastolic and systolic function compared with SHAM groups. E/A ratio, LV posterior and relative wall thickness were lower in the MIP compared with the MI group. There was no interaction between pamidronate administration and MI on systolic function, myocyte hypertrophy, collagen content, and calcium handling proteins. Conclusion: Pamidronate attenuates diastolic dysfunction following MI. Universidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de Botucatu Universidade Estadual Paulista, Departamento de Microbiologia e Imunologia, Instituto de Biociências de Botucatu FAPESP: 2011/10328-8 |
| Databáze: | OpenAIRE |
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