Comparison of the abilities of MHC-compatible bone marrow cells and lymph node cells to induce tolerance of skin allografts in rats
| Autor: | Lise Desquenne-Clark, Willys K. Silvers, Leyla Naji, Hiromitsu Kimura |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Graft Rejection
Cellular immunity Bone Marrow Cells Major histocompatibility complex Immune tolerance Major Histocompatibility Complex Immune system Antigen Bone Marrow Rats Inbred BN medicine Immune Tolerance Animals Transplantation Homologous Lymph node Transplantation biology business.industry Graft Survival Skin Transplantation Histocompatibility Rats medicine.anatomical_structure Animals Newborn Rats Inbred Lew Immunology biology.protein Female Bone marrow Lymph Nodes business |
| Zdroj: | Transplantation. 56(5) |
| ISSN: | 0041-1337 |
| Popis: | A comparison has been made of the abilities of bone marrow cells and lymph node cells to induce tolerance of skin when inoculated into neonatal rats known to differ only with regard to non-MHC incompatibilities, including putative skin-specific (Skn) antigens. Each recipient received 50 x 10(6) cells, and tolerance was confirmed by the permanent acceptance of donor-strain neonatal heart tissue transplanted to the pinna of the ear. In 5 of the 8 MHC-compatible strain combinations tested, BMC were significantly more effective than LNC in inducing tolerance of skin, whereas in one situation LNC proved more efficient. Although the results are in accord with the occurrence of Skn antigens in rats, it appears that at least some of the antigens involved must also be expressed by BMC or LNC, but not equally by both of these tissues. The results also provide evidence that in rats, as in mice, the MHC can play a major role in determining the response to, and/or the immunogenicity of, Skn antigens. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|