Complementary effects of antioxidants and sunscreens in reducing UV-induced skin damage as demonstrated by skin biomarker expression
| Autor: | Christian Oresajo, Margarita Yatskayer, Peter Foltis, Angelike Galdi, Sreekumar Pillai |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Antioxidant Adolescent Ultraviolet Rays medicine.medical_treatment Cassia Pyrimidine dimer Dermatology Pharmacology Placebo medicine.disease_cause Antioxidants Skin Aging Young Adult medicine Humans Skin chemistry.chemical_classification Reactive oxygen species integumentary system biology Plant Extracts business.industry Middle Aged biology.organism_classification Plant Leaves Matrix Metalloproteinase 9 chemistry Pyrimidine Dimers Biomarker (medicine) Drug Therapy Combination Female Surgery Tumor Suppressor Protein p53 business Sunscreening Agents Biomarkers Oxidative stress |
| Zdroj: | Journal of Cosmetic and Laser Therapy. 12:157-162 |
| ISSN: | 1476-4180 1476-4172 |
| DOI: | 10.3109/14764171003674455 |
| Popis: | UV-exposure of the skin causes oxidative stress, leading to inflammatory reactions and premature skin aging. Sunscreens protect by absorbing or reflecting UV on the skin surface. Antioxidants provide protection by quenching UV-induced reactive oxygen species inside skin.To evaluate the complementary photoprotective benefits of formulas containing either an antioxidant complex of Cassia alata leaf extract or a combination of the antioxidant complex and sunscreens on normal healthy volunteers using biomarkers of skin damage.Each formula and a placebo control were applied separately to selected areas on the lower back of 10 individuals for 4 consecutive days. On Day 4, the control and three test sites were exposed to 5 x MED (minimal erythemal dose) of solar-simulated UV-irradiation (UVR). On Day 5, 4-mm punch biopsies were collected from the four exposed sites and a control site (untreated, unexposed) for immunohistochemistry.Exposure to 5 x MED demonstrated significant damage as assessed by thymine dimer formation, MMP-9 and p53 protein expression on untreated exposed skin. The formula containing sunscreens + the antioxidant complex was the most protective, followed by the formula with the antioxidant alone.The study demonstrated that a combination of antioxidants and sunscreens complement each other, resulting in superior photoprotection. |
| Databáze: | OpenAIRE |
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