Complete recovery of renal function in a Wilms' tumor patient after acute renal failure caused by autologous bone marrow transplantation (ABMT)
| Autor: | Ludwig Patzer, D. Fuchs, Felix Zintl, Lutz Hempel, Joachim Misselwitz |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Transplantation Autologous Wilms Tumor Renal Dialysis medicine Humans Renal Insufficiency Etoposide Bone Marrow Transplantation Chemotherapy Kidney business.industry Wilms' tumor Hematology medicine.disease Surgery Transplantation medicine.anatomical_structure Oncology Child Preschool Pediatrics Perinatology and Child Health Hemodialysis Bone marrow business Kidney disease medicine.drug |
| Zdroj: | Pediatric hematology and oncology. 15(3) |
| ISSN: | 0888-0018 |
| Popis: | An autologous bone marrow transplantation (ABMT) was carried out on a 4-year-old boy following the second pulmonary relapse of a nephroblastoma. Glomerular and tubular function of the remaining kidney before ABMT was normal. Etoposide, carboplatin, and melphalan were used in the conditioning regimen. The patient developed acute renal failure (ARF), and hemodialysis was required for 3 weeks. The situation was further complicated by his requiring mechanical ventilation for 12 days. Today, the patient is in good general health and in stable remission 32 months after bone marrow transplantation. This report shows that even serious tubular and glomerular dysfunction may be completely reversible in children. The background for high-dose chemotherapy with ABMT or stem cell rescue is discussed. |
| Databáze: | OpenAIRE |
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