History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China
| Autor: | Linwei Tian, Qing Lan, Larry Z. Liu, Wei Chen, Robert S. Chapman, Xingzhou He, Wei Hu, H. Dean HosgoodIII, Nathaniel Rothman, Hong Lai |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Lung Diseases Male Risk Rural Population Pulmonary and Respiratory Medicine China Cancer Research medicine.medical_specialty Chronic bronchitis Lung Neoplasms Adolescent Population Article Young Adult Smoke Internal medicine medicine Humans Lung cancer education Aged Asthma Aged 80 and over COPD education.field_of_study Lung business.industry Case-control study Odds ratio Middle Aged respiratory system medicine.disease respiratory tract diseases Surgery medicine.anatomical_structure Oncology Air Pollution Indoor Case-Control Studies Female business |
| Zdroj: | Lung Cancer. 81:343-346 |
| ISSN: | 0169-5002 |
| Popis: | History of chronic lung diseases and household coal use for heating and cooking are established risk factors of lung cancer; however, few studies have been able to explore these risk factors simultaneously. Xuanwei, China, has some of the highest rates of lung cancer in China and most residents experience substantial in-home coal smoke exposures. Using a population-based case-control study of 498 lung cancer cases and 498 age-matched controls, we evaluated the risk of lung cancer in relation to coal smoke exposure and history of chronic lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, tuberculosis (TB), chronic bronchitis, and emphysema. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression adjusting for potential confounders. We observed an increased risk of lung cancer with history of any chronic lung disease among males (OR = 14.2; 95%CI = 4.3-46.9), females (OR = 2.6; 95%CI = 1.1-6.3), smokers (OR = 12.7; 95%CI = 3.5-45.8), and nonsmokers (OR = 2.6; 95%CI = 1.1-6.4). Specifically, TB (OR = 83.7; 95%CI = 11.0-634.7), COPD (OR = 3.2; 95%CI = 1.7-6.0), and emphysema and chronic bronchitis (OR = 3.3; 95%CI = 1.7-6.4) were associated with increased risks. These findings suggest that history of chronic lung diseases may also increase risk of lung cancer in populations with indoor coal smoke exposures. |
| Databáze: | OpenAIRE |
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