Activating Killer-Cell Immunoglobulin-Like Receptors Are Associated With the Severity of Coronavirus Disease 2019
| Autor: | Ahmed A. Quadeer, José A. Campillo, Marta Cerezo Moreno, Enrique Bernal, Angeles de la Concha Muñoz, Elisa Martínez-alfaro, María V. Martínez-Sánchez, Alfredo Minguela, Antonia Alcaraz, Matthew R. McKay, María J Alcaraz, Ana Pelaez, Lourdes Gimeno, Marta Hernández-olivo, José Miguel Sáez Gómez, Manuel Muro, Maite Herranz, Elisa García, Alfredo Cano |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Genotype Human leukocyte antigen NK cells Severity of Illness Index Natural killer cell Immunophenotyping 03 medical and health sciences 0302 clinical medicine Receptors KIR HLA Antigens HLA class-I Severity of illness medicine Major Article Immunology and Allergy Humans Genetic Predisposition to Disease Prospective Studies Receptor Aged Lung biology business.industry SARS-CoV-2 COVID-19 Middle Aged COVID-19 severity activating KIR receptors Killer Cells Natural 030104 developmental biology Infectious Diseases medicine.anatomical_structure Cross-Sectional Studies AcademicSubjects/MED00290 Immunology biology.protein Female Antibody business 030215 immunology KIR2DS4 |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 |
| Popis: | Background Etiopathogenesis of the clinical variability of the coronavirus disease 2019 (COVID-19) remains mostly unknown. In this study, we investigate the role of killer cell immunoglobulin-like receptor (KIR)/human leukocyte antigen class-I (HLA-I) interactions in the susceptibility and severity of COVID-19. Methods We performed KIR and HLA-I genotyping and natural killer cell (NKc) receptors immunophenotyping in 201 symptomatic patients and 210 noninfected controls. Results The NKcs with a distinctive immunophenotype, suggestive of recent activation (KIR2DS4low CD16low CD226low CD56high TIGIThigh NKG2Ahigh), expanded in patients with severe COVID-19. This was associated with a higher frequency of the functional A-telomeric activating KIR2DS4 in severe versus mild and/or moderate patients and controls (83.7%, 55.7% and 36.2%, P Conclusions Our results support a crucial role of NKcs in the clinical variability of COVID-19 with specific KIR/ligand interactions associated with disease severity. |
| Databáze: | OpenAIRE |
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