Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster
| Autor: | Agnesa Avanesian, Mahtab Jafari, Jeffery S. Felgner, Behnood Khodayari |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Senescence
Aging media_common.quotation_subject medicine.medical_treatment Longevity Metabolic rate Lamotrigine Bioinformatics Toxicology Life Expectancy Drosophilidae Geriatrics/Gerontology medicine Animals Mortality media_common Dose-Response Relationship Drug Lifespan biology Triazines Mortality rate Life Sciences Cell Biology Calcium Channel Blockers biology.organism_classification Ageing Drosophila melanogaster Anticonvulsant Health span Life expectancy Drosophila Geriatrics and Gerontology Gerontology Locomotion Developmental Biology Research Article medicine.drug |
| Zdroj: | Avanesian, A; Khodayari, B; Felgner, JS; & Jafari, M. (2010). Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster. Biogerontology, 11(1), 45-52. doi: 10.1007/s10522-009-9227-1. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/93t1r004 Biogerontology Avanesian, Agnesa; Khodayari, Behnood; Felgner, Jeffery S.; & Jafari, Mahtab. (2010). Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster. Biogerontology, 11(1), pp 45-52. doi: 10.1007/s10522-009-9227-1. Retrieved from: http://www.escholarship.org/uc/item/02d4z33d |
| ISSN: | 1573-6768 1389-5729 |
| DOI: | 10.1007/s10522-009-9227-1 |
| Popis: | The discovery of life extension in Caenorhabditis elegans treated with anticonvulsant medications has raised the question whether these drugs are prospective anti-aging candidate compounds. The impact of these compounds on neural modulation suggests that they might influence the chronic diseases of aging as well. Lamotrigine is a commonly used anticonvulsant with a relatively good adverse-effects profile. In this study, we evaluated the interaction between the impacts of lamotrigine on mortality rate, lifespan, metabolic rate and locomotion. It has been proposed in a wide range of animal models that there is an inverse relationship between longevity, metabolic rate, and locomotion. We hypothesized that the survival benefits displayed by this compound would be associated with deleterious effects on health span, such as depression of locomotion. Using Drosophila as our model system, we found that lamotrigine decreased mortality and increased lifespan in parallel with a reduction in locomotor activity and a trend towards metabolic rate depression. Our findings underscore the view that assessing health span is critical in the pursuit of useful anti-aging compounds. |
| Databáze: | OpenAIRE |
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