Effect of inhalation exposure to 2-bromopropane on the nervous system in rats
| Autor: | Xiaozhong Yu, Nobuyuki Asaeda, Naomi Hisanaga, Yasuhiro Takeuchi, Zhenlin Xie, Junzoh Kitoh, Gaku Ichihara, Michihiro Kamijima, Eiji Shibata |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Nervous system medicine.medical_specialty Time Factors Neural Conduction Motor nerve Kidney Toxicology Nervous System Nerve conduction velocity chemistry.chemical_compound Internal medicine Administration Inhalation Reaction Time medicine Animals Rats Wistar Myelin Sheath Motor Neurons Inhalation exposure Dose-Response Relationship Drug business.industry Body Weight Brain Peroneal Nerve 2-Bromopropane Organ Size medicine.disease Hydrocarbons Brominated Rats Peripheral neuropathy medicine.anatomical_structure Endocrinology Liver chemistry Anesthesia Toxicity Histopathology business Mutagens |
| Zdroj: | Toxicology. 135:87-93 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/s0300-483x(99)00053-0 |
| Popis: | Exposure to 2-bromopropane (2-BP) is suspected to have adverse effects on the nervous system. The aim of this study was to investigate whether the exposure of rats to 2-BP had neurotoxic effects using histological and electrophysiological studies. Wistar strain male rats were exposed daily to either 100 or 1000 ppm 2-BP or to fresh air for 8 h a day for 12 weeks. Body weight was measured before exposure and every 2 weeks. Motor nerve conduction velocity (MCV) and distal latency (DL) were measured before exposure and every 4 weeks during exposure. Histological examination of the nervous system was also performed. Exposure of rats (n = 9) to 1000 ppm resulted in suppression of body weight gain and a significant decrease in brain weight compared to the control (n = 9). Electrophysiological measurements showed a significant decrease in MCV in 1000 ppm exposed rats at 8 weeks and significant prolongation of DL at 8 and 12 weeks. Abnormalities of the myelin sheath were detected in the common peroneal nerves. In 100-ppm exposed rats (n = 9), no significant changes were noted in body weight and the peripheral nerve. In conclusions, long-term exposure to 1000 ppm of 2-BP may result in peripheral neuropathy in rats. |
| Databáze: | OpenAIRE |
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