Gastrointestinal stromal tumors: prognostic factors and therapeutic implications
| Autor: | Rosa, Fausto, Alfieri, Sergio, Tortorelli, Ap, Di Miceli, D, Papa, V, Ricci, Riccardo, Doglietto, Gb |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research Gastrointestinal Stromal Tumors Settore MED/18 - CHIRURGIA GENERALE Antineoplastic Agents Kaplan-Meier Estimate Risk Assessment Disease-Free Survival Medical Records 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Recurrence Risk Factors Humans Molecular Targeted Therapy Digestive System Surgical Procedures Aged Gastrointestinal Neoplasms Retrospective Studies Aged 80 and over Analysis of Variance Settore MED/08 - ANATOMIA PATOLOGICA General Medicine Middle Aged Prognosis Treatment Outcome Oncology Chemotherapy Adjuvant Drug Resistance Neoplasm 030220 oncology & carcinogenesis Female Neoplasm Recurrence Local Follow-Up Studies |
| Zdroj: | Tumori. 98(3) |
| ISSN: | 2038-2529 |
| Popis: | Background Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the digestive tract. They have recently been recognized as a separate nosological entity and the literature on these stromal tumors has rapidly expanded. Materials and methods The surgical records of 50 patients with primary GISTs treated at the Digestive Surgery Department of the Catholic University of Rome from January 1993 to December 2010 were reviewed and the prognostic factors were analyzed. Results Surgery was performed in all patients with curative intent. The median age at presentation was 66.5 years (range, 28–81). Adjuvant therapy was administered in 26 (52%) cases. Median follow-up was 71 months (range, 5–208). There was an 8% recurrence rate. The actuarial 5-year overall and disease-free survival rates were 66.3% and 57.2%, respectively. High mitotic rate (P Conclusions The present study confirmed the important role of aggressive surgical management of GISTs to offer these patients the most appropriate treatment for long-term survival. |
| Databáze: | OpenAIRE |
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