THE EFFECT OF ADRENOCORTICOTROPHIN ON THE NUCLEIC ACID METABOLISM OF THE RAT ADRENAL GLAND
| Autor: | F. Antoni, R. C. Imrie, T. R. Ramaiah, W. C. Hutchison |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
medicine.medical_specialty
Biochemical Phenomena Endocrinology Diabetes and Metabolism Mitochondrion Biochemistry Chemistry Techniques Analytical Phosphorus metabolism Nucleic acid metabolism chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Microsomes Internal medicine Adrenal Glands medicine Cell Nucleus Pharmacology Research RNA Phosphorus DNA Metabolism Mitochondria Rats Cell nucleus medicine.anatomical_structure chemistry Microsome |
| Zdroj: | Journal of Endocrinology. 32:303-312 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.0320303 |
| Popis: | SUMMARY Treatment of female rats with adrenocorticotrophin (ACTH) increased the RNA content of the adrenal glands progressively during a period of 3 days, the DNA content increased only after prolonged administration. By contrast, ACTH caused a decrease in the uptake of [32P]orthophosphate into the total RNA of the gland and into most of the RNA fractions of the subcellular components. A method of analysis for RNA and DNA based on the Schmidt-Thannhauser procedure has been evolved which eliminates extraction of nucleic acid by lipid solvents. |
| Databáze: | OpenAIRE |
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