Association of abnormal erythrocyte morphology with oxidative stress and inflammation in metabolic syndrome
| Autor: | Ross S. Richards, Ezekiel Uba Nwose, Prajwal Gyawali, Phillip Bwititi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Erythrocyte Aggregation Erythrocyte Indices Male medicine.medical_specialty Free Radicals Echinocyte Blood viscosity Erythrocytes Abnormal Isoprostanes Biology medicine.disease_cause Erythrocyte aggregation Superoxide dismutase Erythrocyte Deformability Internal medicine medicine Humans Erythrocyte deformability Molecular Biology Inflammation Metabolic Syndrome medicine.diagnostic_test Superoxide Dismutase Cell Biology Hematology Blood Viscosity Glutathione Oxidative Stress C-Reactive Protein Endocrinology Case-Control Studies Immunology biology.protein Molecular Medicine Female Hemorheology Lipid profile Biomarkers Oxidative stress |
| Zdroj: | Blood Cells, Molecules, and Diseases. 54:360-363 |
| ISSN: | 1079-9796 |
| DOI: | 10.1016/j.bcmd.2015.01.005 |
| Popis: | In carrying out their role of free radical scavenging, erythrocytes become damaged due to oxidation of membrane lipids and proteins. Such damage may change the morphology of the erythrocytes. The present study aims to demonstrate change in erythrocyte morphology in MetS and associate the changes with increased oxidative stress and inflammation that were shown in our recent study. One hundred participants were recruited from a rural town of Australia. Whole blood viscosity, erythrocyte aggregation, erythrocyte deformability, lipid profile and blood sugar level, oxidative stress markers (erythrocyte reduced glutathione, superoxide dismutase, urinary isoprostanes) and inflammatory markers (high sensitivity C-reactive protein) were measured. Erythrocyte morphological study was performed by scanning electron microscopy. Recruited participants were classified into MetS and non-MetS following the National Cholesterol Education Program Adult Treatment Panel III definition. Data were analyzed by IBM SPSS 20 software. The mean percentages of biconcave cells were decreased whereas acanthocytes, stomatocytes and echinocytes were increased in MetS group compared to healthy controls. Morphologically abnormal erythrocytes were significantly correlated with oxidative stress and chronic inflammation markers. Free radicals generated in increased concentration in MetS seem to damage erythrocyte changing its morphology which possibly could affect other hemorheological parameters. |
| Databáze: | OpenAIRE |
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