Metabolic and Hormonal Profile of Adolescent Girls With Polycystic Ovary Syndrome With Concomitant Autoimmune Thyroiditis
| Autor: | Aneta Gawlik, Agnieszka Zachurzok, Karolina Skrzynska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
metabolic disorder Thyroid Hormones Adolescent Endocrinology Diabetes and Metabolism Population Thyroid Gland Physiology 030209 endocrinology & metabolism Diseases of the endocrine glands. Clinical endocrinology Autoimmune thyroiditis 03 medical and health sciences adolescent girls Endocrinology 0302 clinical medicine Thyroid peroxidase cardiovascular disease Statistical significance medicine Humans Insulin Child education Retrospective Studies Original Research education.field_of_study 030219 obstetrics & reproductive medicine Estradiol biology business.industry Thyroid Metabolic disorder Thyroiditis Autoimmune autoimmune thyroiditis Prognosis medicine.disease RC648-665 Polycystic ovary medicine.anatomical_structure polycystic ovary syndrome biology.protein Female business Biomarkers Follow-Up Studies Hormone |
| Zdroj: | Frontiers in Endocrinology, Vol 12 (2021) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| Popis: | IntroductionBoth polycystic ovary syndrome (PCOS) and autoimmune thyroiditis (AT) are considered to be among the most common endocrinopathies in young women, and they are classified as diseases that affect many processes in the human body. Their role in the development of metabolic disorders and diseases of the cardiovascular system in adult women is also emphasized. However, there are no data available to assess such risk in the teenage girl population. The aim of the study was to assess the hormonal and metabolic profile of adolescent girls with PCOS, additionally diagnosed with AT, as well as to identify possible risk factors for the coexistence of AT and PCOS.Material and Methods80 euthyroidic PCOS patients were qualified for the study (chronological age 16.54 ± 1.00 years, BMI 24.60 ± 4.16 kg/m2). Eighteen girls diagnosed with AT were included in the study group and 62 girls without AT—in the control group. Each patient had biochemical and hormonal tests performed. Additionally, to diagnose AT, the level of antibodies against thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG), as well as the image of the thyroid gland on ultrasound examination, were taken into account.ResultsEstradiol concentration was significantly higher in the study than in the control group (203.00 ± 217.00 vs. 152.00 ± 78.50 pmol/L, p=0.02). Higher DHEAS concentrations were also observed in the AT group compared with the group without AT (391.28 ± 176.40 vs. 317.93 ± 114.27 µg/dl, p=0.04). Moreover, there was a positive correlation between AT and estradiol concentration (ry=0.27; p=0.04). It was also shown that there is a tendency toward statistical significance for the positive correlation between the positive anti-TPO titer and the glucose concentration at 120 min OGTT (rƴ=0.26; p=0.07) and girls with PCOS and AT had higher glucose levels in 120 min OGTT (115.29±41.70 vs. 98.56±28.02 mg/dl, p=0.08).ConclusionThe study results showed no difference in the metabolic profile between the groups. The high concentration of estradiol found in girls with PCOS and AT may indicate the role of this hormone in the development of the autoimmune process. However, the numbers are small, and more research is needed to confirm our findings. |
| Databáze: | OpenAIRE |
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