Transmembrane potentials in the rat myometrium during pregnancy
| Autor: | Theodore C. West, Jorge F. Landa, John B. Thiersch |
|---|---|
| Rok vydání: | 1959 |
| Předmět: |
Membrane potential
Pregnancy medicine.medical_specialty Chemistry Obstetrics Uterus Myometrium medicine.disease Transmembrane protein Membrane Potentials Rats Cell biology Microelectrode medicine.anatomical_structure Physiology (medical) medicine Animals Humans Female reproductive and urinary physiology Intracellular |
| Zdroj: | American Journal of Physiology-Legacy Content. 196:901-904 |
| ISSN: | 0002-9513 |
| DOI: | 10.1152/ajplegacy.1959.196.4.901 |
| Popis: | Isolated segments of the uteri of pregnant and nonpregnant Long-Evans rats were studied by the microelectrode technique of intracellular recordings. Both action and resting membrane potentials were recorded in the following states: nonpregnant; 12, 15 and 21 days pregnant; and 24 hours postpartum. The results indicated that the magnitude of the resting membrane potential increased with advancing pregnancy when observed from areas exclusive of the sites of placental attachment. However, resting potentials from placental sites were maximum at 12 and 15 days pregnancy. The frequency of spontaneous spike discharge was greatest in nonpregnant uteri and in early pregnancy declining to a minimum at 24 hours postpartum. Oxytocin increased the frequency of spike discharge and increased the duration of repetitive action potential trains. This effect was greatest in early pregnancy and in the nonpregnant uterus. |
| Databáze: | OpenAIRE |
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