Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception
Autor: | Ahne Myklatun, Stephan H. K. Eder, Michael Winklhofer, Gil G. Westmeyer, Denis Shcherbakov, Michele Cappetta, Wolfgang Wurst, Antonella Lauri |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
animal structures Science Unfamiliar environment Oryzias General Physics and Astronomy Hindbrain Biology Locomotor activity Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences biology.animal Genetic model Animals Author Correction lcsh:Science Zebrafish reproductive and urinary physiology Neurons Multidisciplinary Behavior Animal fungi Vertebrate Magnetoreception General Chemistry Darkness biology.organism_classification Neuronal activation Rhombencephalon Magnetic Fields 030104 developmental biology embryonic structures lcsh:Q human activities Neuroscience Locomotion |
Zdroj: | Nat. Commun. 9:802 (2018) Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018) Nature Communications |
ISSN: | 2041-1723 |
DOI: | 10.1038/s41467-018-03090-6 |
Popis: | An impediment to a mechanistic understanding of how some species sense the geomagnetic field (“magnetoreception”) is the lack of vertebrate genetic models that exhibit well-characterized magnetoreceptive behavior and are amenable to whole-brain analysis. We investigated the genetic model organisms zebrafish and medaka, whose young stages are transparent and optically accessible. In an unfamiliar environment, adult fish orient according to the directional change of a magnetic field even in darkness. To enable experiments also in juveniles, we applied slowly oscillating magnetic fields, aimed at generating conflicting sensory inputs during exploratory behavior. Medaka (but not zebrafish) increase their locomotor activity in this assay. Complementary brain activity mapping reveals neuronal activation in the lateral hindbrain during magnetic stimulation. These comparative data support magnetoreception in teleosts, provide evidence for a light-independent mechanism, and demonstrate the usefulness of zebrafish and medaka as genetic vertebrate models for studying the biophysical and neuronal mechanisms underlying magnetoreception. Advances in animal magnetoreception have been limited by a lack of tractable vertebrate laboratory models. Here, the authors demonstrate light-independent magnetoreception in mature zebrafish and medaka, as well as magnetosensitive locomotion in juvenile medaka associated with neuronal activation in the lateral hindbrain. |
Databáze: | OpenAIRE |
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