Visfatin Is Regulated by Rosiglitazone in Type 2 Diabetes Mellitus and Influenced by NFκB and JNK in Human Abdominal Subcutaneous Adipocytes

Autor: K. C. McGee, Gyanendra Tripathi, Sudhesh Kumar, Marc Evans, Nasser M. Al-Daghri, S. J. Creely, M. Khanolkar, Paul L. Levick, Philip G. McTernan, Alison L. Harte, Christine M. Kusminski, Nancy F. da Silva, Madhu V. Chittari, Vinod Patel
Rok vydání: 2011
Předmět:
Male
Anatomy and Physiology
medicine.medical_treatment
Nicotinamide phosphoribosyltransferase
lcsh:Medicine
Adipose tissue
Cell Separation
Signal transduction
chemistry.chemical_compound
Molecular cell biology
Endocrinology
Adipocytes
Insulin
Medicine
Phosphorylation
lcsh:Science
Nicotinamide Phosphoribosyltransferase
Adiposity
Multidisciplinary
NF-kappa B
Signaling cascades
Immunohistochemistry
c-Jun N-terminal kinase signaling cascade
Recombinant Proteins
I-kappa B Kinase
Cytokines
Female
Rosiglitazone
Research Article
medicine.drug
Adult
Drugs and Devices
medicine.medical_specialty
Adipokine
Endocrine System
Proinflammatory cytokine
Adipokines
Downregulation and upregulation
Internal medicine
Humans
Obesity
Biology
Nutrition
Diabetic Endocrinology
Endocrine Physiology
Tumor Necrosis Factor-alpha
business.industry
lcsh:R
JNK Mitogen-Activated Protein Kinases
Diabetes Mellitus Type 2
Subcutaneous Fat
Abdominal
Diabetes Mellitus
Type 2
Gene Expression Regulation
chemistry
Immune System
Case-Control Studies
Culture Media
Conditioned
lcsh:Q
Clinical Immunology
Thiazolidinediones
Resistin
business
Zdroj: PLoS ONE
PLoS ONE, Vol 6, Iss 6, p e20287 (2011)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0020287
Popis: Visfatin has been proposed as an insulin-mimicking adipocytokine, predominantly secreted from adipose tissue and correlated with obesity. However, recent studies suggest visfatin may act as a proinflammatory cytokine. Our studies sought to determine the significance of this adipocytokine and its potential role in the pathogenesis of T2DM. Firstly, we examined the effects of diabetic status on circulating visfatin levels, and several other adipocytokines, demonstrating that diabetic status increased visfatin*, TNF-α*** and IL-6*** compared with non-diabetic subjects (*p
Databáze: OpenAIRE
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