TGF-β in jaw tumor fluids induces RANKL expression in stromal fibroblasts
| Autor: | Chiaki Yamada, Katsuhiko Amano, Seiji Iida, Emi Okuno, Sosuke Takahata, Kazuaki Miyagawa, Tomonao Aikawa, Mikihiko Kogo, Masaaki Kimata, Masaya Okura |
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| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
interleukin-1α Odontogenic Tumors Bone resorption Transforming Growth Factor beta1 03 medical and health sciences 0302 clinical medicine Stroma Osteoclast Transforming Growth Factor beta Interleukin-1alpha medicine Tumor Cells Cultured Humans Prostaglandin E2 receptor activator of NF-κB ligand biology Cyst Fluid odontogenic tumor RANK Ligand Osteoprotegerin keratocystic odontogenic tumor transforming growth factor-β 030206 dentistry Articles Fibroblasts Jaw Neoplasms Recombinant Proteins Resorption medicine.anatomical_structure Oncology RANKL 030220 oncology & carcinogenesis Odontogenic Cysts Cancer research biology.protein Keratocystic Odontogenic Tumor Stromal Cells Transforming growth factor medicine.drug |
| Zdroj: | International Journal of Oncology |
| ISSN: | 1791-2423 |
| Popis: | Odontogenic tumors and cysts, arising in the jawbones, grow by resorption and destruction of the jawbones. However, mechanisms underlying bone resorption by odontogenic tumors/cysts remain unclear. Odontogenic tumors/cysts comprise odontogenic epithelial cells and stromal fibroblasts, which originate from the developing tooth germ. It has been demonstrated that odontogenic epithelial cells of the developing tooth germ induce osteoclastogenesis to prevent the tooth germ from invading the developing bone to maintain its structure in developing bones. Thus, we hypothesized that odontogenic epithelial cells of odontogenic tumors/cysts induce osteoclast formation, which plays potential roles in tumor/cyst outgrowth into the jawbone. The purpose of this study was to examine osteoclastogenesis by cytokines, focusing on transforming growth factor-β (TGF-β), produced by odontogenic epithelial cells. We observed two pathways for receptor activator of NF-κB ligand (RANKL) induction by keratocystic odontogenic tumor fluid: the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway through interleukin-1α (IL-1α) signaling and non-COX-2/PGE2 pathway through TGF-β receptor signaling. TGF-β1 and IL-1α produced by odontogenic tumors/cysts induced osteoclastogenesis directly in the osteoclast precursor cells and indirectly via increased RANKL induction in the stroma. |
| Databáze: | OpenAIRE |
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