Histological and biomechanical properties of systemic arteries in young and old Warmblood horses

Autor: Gunther van Loon, Koen Chiers, Annelies Decloedt, Glenn Van Steenkiste, Sofie Muylle, Patrick Segers, Lisse Vera
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Aging
SMOOTH-MUSCLE-CELL
COLLAGEN TYPE-I
Median artery
Smooth Muscle Cells
030204 cardiovascular system & hematology
Biochemistry
Carotid Intima-Media Thickness
DISEASE
ELASTIC PROPERTIES
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Common Carotid Arteries
Medicine
Common carotid artery
Aorta
Mammals
0303 health sciences
Multidisciplinary
biology
Age Factors
Eukaryota
WALL
Arteries
Anatomy
Warmblood
medicine.anatomical_structure
Vertebrates
cardiovascular system
Cellular Types
Research Article
Science
Equines
Muscle Tissue
Sudden death
MEDIA
03 medical and health sciences
AGE
medicine.artery
Animals
Veterinary Sciences
Horses
Vascular Diseases
030304 developmental biology
Muscle Cells
Rupture
Spontaneous
business.industry
Organisms
Biology and Life Sciences
Proteins
External iliac artery
Cell Biology
Femoral Arteries
Elastin
Biological Tissue
Intima-media thickness
TISSUE
Amniotes
Cardiovascular Anatomy
biology.protein
Blood Vessels
business
Zoology
Collagens
Zdroj: PLoS ONE, Vol 16, Iss 7, p e0253730 (2021)
PLoS ONE
PLOS ONE
ISSN: 1932-6203
Popis: Arterial rupture is a well-recognized cause of sudden death in horses, which mainly affects older horses. The arterial wall is known to stiffen with age, although the underlying age-related histological and biomechanical changes remain unclear. The purpose of this study was to investigate the effect of aging by histological analysis of the arterial wall and examination of the arterial wall biomechanical properties using an inflation-extension test. Entire circular samples of the proximal and distal aorta, cranial and caudal common carotid, external iliac, femoral and median artery were collected from 6 young (6 years) and 14 old horses (≥15 years). Samples of all arteries were histologically examined and intima media thickness as well as area % of elastin, smooth muscle actin and collagen type I and III were determined. Older horses had a significantly larger intima media thickness and a significantly higher area % of smooth muscle actin compared to young horses. Samples of the proximal and distal aorta, the caudal common carotid and the external iliac artery were mechanically assessed using an in-house developed inflation-extension device with ultrasound analysis. Rupture occurred in a minority of arteries (8/78) at high pressures (between 250–300 mmHg), and mostly occurred in older horses (7/8). Pressure-area, pressure-compliance and pressure-distensibility curves were constructed. A significant difference in the pressure-area curves of the distal aorta, common carotid artery and external iliac artery, the pressure-compliance curves of the proximal aorta and carotid artery and the pressure-distensibility curve of the proximal aorta was observed between young and old horses. Results demonstrate an effect of age on the histological and biomechanical properties of the arterial wall, which might explain why arterial rupture occurs more often in older horses.
Databáze: OpenAIRE
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