Evaluation of the effect of vitamin D supplementation on spermatogram, seminal and serum levels of oxidative stress indices in asthenospermia infertile men: a study protocol for a triple-blind, randomized controlled trial
| Autor: | Mohammadreza Dadfar, Ahmad Zare Javid, Anahita Mansoori, Amirarsalan Serajian, Leila Maghsoumi-Norouzabad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Idiopathic asthenospermia RC620-627 Medicine (miscellaneous) Parathyroid hormone 030209 endocrinology & metabolism Asthenozoospermia Infertile men Study Protocol 03 medical and health sciences chemistry.chemical_compound Semen quality 0302 clinical medicine Semen Internal medicine medicine Vitamin D and neurology Humans Testosterone Sex hormones TX341-641 Vitamin D Nutritional diseases. Deficiency diseases Infertility Male Sperm motility Randomized Controlled Trials as Topic 030219 obstetrics & reproductive medicine Nutrition and Dietetics business.industry Free androgen index Nutrition. Foods and food supply medicine.disease Sperm Semen Analysis Endocrinology chemistry Oxidative stress Dietary Supplements Sperm Motility business |
| Zdroj: | Nutrition Journal, Vol 20, Iss 1, Pp 1-11 (2021) Nutrition Journal |
| ISSN: | 1475-2891 2015-1128 |
| Popis: | Background It is suggested that vitamin D may have a beneficial role in male reproduction. The male reproductive system is a target tissue for vitamin D. This study will aim to evaluate the effects of vitamin D supplementation on sperm parameters, seminal and serum levels of oxidative stress and serum endocrine factors in asthenospermia infertile men. Methods/design This randomized, triple-blind, placebo-controlled clinical trial will be conducted on 86 infertile men with idiopathic asthenozoospermia (the mobility of sperm Main outcomes measure (s) Demographic data, dietary intake, physical activity, sun exposure, anthropometric indices, serum and seminal levels of MDA (Malondialdehyde), 8-hydroxy-2- Dioxy Guanosine (8-OHDG), Total Antioxidant Capacity (TAC) and calcium, sperm DNA fragmentation index (DFI), serum 25-OHD, luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), estradiol (E2), sex hormone-binding globulin (SHBG), free androgen index (FAI = T/SHBG. 100), T/LH and T/E2 ratios, prolactin (PRO), parathyroid hormone (PTH), osteocalcin (OCN), phosphorus and sperm parameters. Discussion The deficiency of vitamin D as an antioxidant is common all over the world. Numerous observational studies have shown a positive association between vitamin D levels and semen quality. However, few clinical studies have been conducted in this area. So considering with the high prevalence of this antioxidant deficiency specifically in infertile men, it seems that the supplementation of vitamin D in infertile men with insufficient levels or deficiency may improve the status of oxidative stress and thereby may affect sperm parameters and endocrine factors involved in male fertility. Trial registration Iran Clinical Trials Registry, ID: IRCT20151128025274N4, registered on 28 March 2018. |
| Databáze: | OpenAIRE |
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