Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats
| Autor: | Bekusova Viktoria V., Patsanovskii Vasily M., Nozdrachev Alexander D., Trashkov Alexandr P., Artemenko Margarita R., Anisimov Vladimir N. |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty endocrine system 1 2-dimethylhydrazine Colorectal cancer medicine.medical_treatment medicine.disease_cause lcsh:RC254-282 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine prevention Internal medicine medicine rat biology business.industry Insulin medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Metformin Colon cancer 1 2-Dimethylhydrazine 030104 developmental biology Endocrinology Oncology chemistry Catalase 030220 oncology & carcinogenesis biology.protein Original Article Glycated hemoglobin Carcinogenesis business metformin Hormone medicine.drug |
| Zdroj: | Cancer Biology & Medicine Cancer Biology & Medicine, Vol 14, Iss 1, Pp 100-107 (2017) |
| ISSN: | 2095-3941 |
| Popis: | Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulin-like growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer. |
| Databáze: | OpenAIRE |
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