Alterations of Central Vasopressinergic System in Transgenic Rats with Low Brain Angiotensinogen

Autor:	Baltatu, O., Couto, As, Santos, Ras, Ganten, D., Campagnole-Santos, Mj, Bader, M.
Rok vydání:	2000
Předmět:	nervous system Internal Medicine hormones hormone substitutes and hormone antagonists
Zdroj:	ResearcherID
ISSN:	1524-4563 0194-911X
Popis:	P188 The consequence of a permanent alteration of the brain renin-angiotensin system (RAS) on central vasopressinergic system was studied at the level of the nucleus tractus solitarii (NTS) of transgenic rats with a deficit in brain angiotensinogen, TGR(ASrAOGEN). Vasopressin (AVP) (100 pmol/ 50nl) or desmopressin (DDAVP, V2 receptor agonist) (100pmol/ 50nl) were microinjected into the NTS of urethane-anesthetized TGR(ASrAOGEN) and Sprague-Dawley (SD) rats. Blood pressure and heart rate were measured via a femoral artery catheter and the baroreflex induced by phenylephrine (baroreflex bradycardia) evaluated. Hypothalamic levels of AVP mRNA were measured by ribonuclease protection assay (RPA). AVP microinjections induced a greater decrease of the MAP in TGR(ASrAOGEN) in comparison with SD rats (-19.9 ± 5.2 vs. -7.5 ± 0.7 mmHg, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041762b02aeed73b3c44cd628125782d https://doi.org/10.1161/hyp.36.suppl_1.727-b Zobrazit plný text záznamu