API-polymer interactions in Sepineo P600 based topical gel formulation- impact on rheology

Autor: Abu Zayed Md Badruddoza, Thean Yeoh, Jaymin C. Shah
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Pharmaceutics. 621:121824
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2022.121824
Popis: In the present study, topical gel and emulsion gel were formulated using Acrylamide/ Sodium Acryloyldimethyl taurate copolymer (Sepineo P600) as a gelling agent, and their rheological attributes and physical stability were evaluated upon incorporation of API. Lidocaine, a free base drug (pK
Databáze: OpenAIRE