Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines
| Autor: | Irina Petrushina, David H. Cribbs, Hayk Davtyan, Lars Østergaard Pedersen, Anahit Ghochikyan, David Flyer, Jianmei Yu, Peter Juul Madsen, Michael G. Agadjanyan, Armine Hovakimyan |
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| Rok vydání: | 2014 |
| Předmět: |
Alzheimer Vaccines
medicine.drug_class medicine.medical_treatment Bacterial Toxins Immunology Epitopes T-Lymphocyte Transdermal Patch Enzyme-Linked Immunosorbent Assay Enterotoxin Biology Antibodies Viral Lymphocyte Activation medicine.disease_cause Immunostimulant Article Gene gun law.invention Enterotoxins Mice Immune system Adjuvants Immunologic law Escherichia coli Vaccines DNA medicine Animals Immunology and Allergy Amyloid beta-Peptides Escherichia coli Proteins Vaccination Virology Mice Inbred C57BL Disease Models Animal Neurology Recombinant DNA Epitopes B-Lymphocyte Female Neurology (clinical) Adjuvant |
| Zdroj: | Journal of Neuroimmunology. 268:50-57 |
| ISSN: | 0165-5728 |
| Popis: | Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulatory patches (LT-IS) dramatically enhances the onset and magnitude of immune responses to DNA- and protein-based vaccines for Alzheimer's disease following intradermal immunization via gene gun and conventional needles, respectively. Our studies suggest that the immune activation mediated by LT-IS offers improved potency for generating AD-specific vaccination responses that should be investigated as an adjuvant in the clinical arena. |
| Databáze: | OpenAIRE |
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