Implications ofHaemophilus influenzaeBiogroupaegyptiusHemagglutinins in the Pathogenesis of Brazilian Purpuric Fever
| Autor: | S Hoshino-Shimizu, Sônia França Correia Barbosa, Maria das Graças Adelino Alkmin, Hiro Goto |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Haemophilus influenzae biogroup aegyptius Haemophilus Infections Virulence medicine.disease_cause Haemophilus influenzae Microbiology Pathogenesis Bacterial Proteins medicine Extracellular Animals Humans Immunology and Allergy Brazilian purpuric fever Purpura biology Pasteurellaceae biology.organism_classification medicine.disease Virology Hemagglutinins Infectious Diseases Rabbits Brazil Bacteria |
| Zdroj: | The Journal of Infectious Diseases. 188:74-80 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Brazilian purpuric fever (BPF) is an acute disease caused by Haemophilus influenzae biogroup aegyptius; it is characterized by fever, purpura, and hypotensive shock and is usually fatal. The factors responsible for bacterial virulence and pathogenesis are poorly known. Hemagglutinins have been frequently associated with bacterial virulence, and, in the present study, hemagglutinating activity was detected in extracellular products from H. influenzae biogroup aegyptius strains isolated from patients with BPF. A 60-kilodalton (kDa) molecule absorbable by human O-type erythrocytes was identified by an immunoblot assay; a corresponding fraction was chromatographically purified, and its pathogenic effect was evaluated. Rabbits injected intravenously with either the whole bacterial extracellular product or the 60-kDa fraction showed reactions similar to those seen in patients with BPF: purpura, congestion, and fibrin thrombi in the inner organs. We suggest that this hemagglutinating factor is one of the major pathogenic components of BPF. |
| Databáze: | OpenAIRE |
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