Sensitivity of human leukemic cells to anti-cancer agents in culture
| Autor: | Ming Y. Chu, Marvin L. Hoovis |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Azauridine
Cells Cell Drug Resistance Antineoplastic Agents Biology Biochemistry Mice medicine Animals Humans Horses Thioguanine Cyclophosphamide Cells Cultured Pharmacology Leukemia Experimental Mercaptopurine Cytarabine Cancer medicine.disease In vitro Culture Media Methotrexate medicine.anatomical_structure Vincristine Immunology Cancer research Prednisone Chlorambucil Floxuridine |
| Zdroj: | Biochemical Pharmacology. 23:503-511 |
| ISSN: | 0006-2952 |
| Popis: | Special-conditioned medium prepared from overgrown cultures of murine leukemic cells was found to support short-term reproduction (24–96 hr) of human leukemic cells in culture. Failure of three preparations to grow in culture may be due to the instability of the special medium when stored for more than 5 days. Leukemic cell preparations from 12 patients had a variable growth response in vitro and also exhibited a different and characteristic sensitivity to anti-cancer agents. The selection of specific anti-cancer agents for treatment of leukemic patients may be possible with the development of this drug-sensitivity test in vitro . |
| Databáze: | OpenAIRE |
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