Abnormalities of CSF flow patterns in the cerebral aqueduct in treatment-resistant late-life depression: A potential biomarker of microvascular angiopathy
| Autor: | Robert C. Baldwin, Tufail Patankar, John C. Waterton, Suzanne Jeffries, Josephine H. Naish, Christopher J. Taylor, Alistair Burns, Alan Jackson |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Pathology Drug Resistance Microcirculation Angiopathy Cerebrospinal fluid Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Depression (differential diagnoses) Aged Aged 80 and over medicine.diagnostic_test Depression business.industry Cerebral Aqueduct Magnetic resonance imaging Middle Aged Late life depression Prognosis medicine.disease Magnetic Resonance Imaging Antidepressive Agents Cerebrovascular Disorders Cerebrovascular Circulation Cerebral aqueduct Cardiology Feasibility Studies Biomarker (medicine) Female business Blood Flow Velocity |
| Zdroj: | Magnetic Resonance in Medicine. 56:509-516 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.20999 |
| Popis: | There is growing evidence that microvascular angiopathy (MVA) plays an important role in the development of dementia and affective disorders in older people. At currently available image resolutions it is not possible to image directly the vascular changes associated with MVA, but the effects on blood and cerebrospinal fluid (CSF) flow may be detectable. The aim of this study was to investigate a potential biomarker for MVA based on MRI of abnormalities in CSF flow. Since there is considerable indirect evidence that treatment resistance in late-onset depressive disorder is related to MVA, we assessed the method in a group of 22 normal volunteers and 29 patients with responsive (N=21) or treatment-resistant (N=8) late-onset depressive disorder. Single-slice quantified phase-contrast (PC) images of cerebral blood and CSF flow were collected at 15 points over a cardiac cycle, and the resulting flow curves were parameterized. Significant differences in the CSF flow (width of systolic flow peak and diastolic flow volume, both P |
| Databáze: | OpenAIRE |
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