Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?
| Autor: | Luigina Micolucci, Maria Rita Rippo, Antonio Ceriello, Angelica Giuliani, Antonio Domenico Procopio, Francesco Prattichizzo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Senescence Immunology Inflammation Review Article Mitochondrion Biology medicine.disease_cause DNA Mitochondrial Proinflammatory cytokine 03 medical and health sciences microRNA lcsh:Pathology medicine Humans Epigenetics Cellular Senescence NF-kappa B Cell Biology Mitochondria Cell biology MicroRNAs Oxidative Stress 030104 developmental biology medicine.symptom Reactive Oxygen Species Corrigendum Cell aging Oxidative stress lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2017 (2017) |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | A relevant feature of aging is chronic low-grade inflammation, termed inflammaging, a key process promoting the development of all major age-related diseases. Senescent cells can acquire the senescence-associated (SA) secretory phenotype (SASP), characterized by the secretion of proinflammatory factors fuelling inflammaging. Cellular senescence is also accompanied by a deep reshaping of microRNA expression and by the modulation of mitochondria activity, both master regulators of the SASP. Here, we synthesize novel findings regarding the role of mitochondria in the SASP and in the inflammaging process and propose a network linking nuclear-encoded SA-miRNAs to mitochondrial gene regulation and function in aging cells. In this conceptual structure, SA-miRNAs can translocate to mitochondria (SA-mitomiRs) and may affect the energetic, oxidative, and inflammatory status of senescent cells. We discuss the potential role of several of SA-mitomiRs (i.e., let-7b, miR-1, miR-130a-3p, miR-133a, miR-146a-5p, miR-181c-5p, and miR-378-5p), using miR-146a as a proof-of-principle model. Finally, we propose a comprehensive, metabolic, and epigenetic view of the senescence process, in order to amplify the range of possible approaches to target inflammaging, with the ultimate goal of decelerating the aging rate, postponing or blunting the development of age-related diseases. |
| Databáze: | OpenAIRE |
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