The role of COX-2 in rectal cancer treated with preoperative radiotherapy
| Autor: | Philippe Coucke, Pu Yan, Henri Vuilleumier, Hanifa Bouzourene, Abderrahim Zouhair, Maurice Matter, Dominique Sandmeier |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Preoperative radiotherapy Colorectal cancer medicine.medical_treatment Inflammation Adenocarcinoma Aged Aged 80 and over Cyclooxygenase 2 Female Humans Middle Aged Neoplasm Recurrence Local Preoperative Care Prognosis Rectal Neoplasms Retrospective Studies Survival Analysis Treatment Outcome Tumor response Pathology and Forensic Medicine Internal medicine medicine Molecular Biology business.industry Cancer Anatomical pathology Cell Biology General Medicine medicine.disease Surgery Radiation therapy Immunohistochemistry medicine.symptom business |
| Zdroj: | Virchows Archiv, vol. 452, no. 5, pp. 499-505 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-008-0606-9 |
| Popis: | Radiotherapy is one of the principal modalities of rectal cancer treatment, and the ability to predict radio resistance could potentially improve survival through a targeted treatment approach. Cyclooxygenase-2 (COX-2) may protect against damage by irradiation that would justify the use of COX-2 inhibitors. The purpose of this study was to investigate the potential role of COX-2 in tumor response and outcome of patients with rectal cancer treated preoperatively with radiotherapy. Using immunohistochemistry, we examined COX-2 expression in 88 surgical specimens of rectal cancer treated preoperatively and in 26 pretherapeutic biopsies. We tested whether COX-2 expression was correlated with clinico-pathologic parameters and with survival and local recurrence. COX-2 was expressed in 50% of the pretherapeutic tumor biopsies and in 88.6% of post-irradiated surgical samples. COX-2 expression was correlated only with enhanced tumor inflammation (p = 0.03) and with tumor volume exceeding 30 cc (p = 0.05). COX-2 was not significantly correlated with patient survival, but none of the patients with COX-2 negative tumors did recur locally, whereas 80% of patients with local recurrences have COX-2 positive tumors. We conclude that COX-2 expression is overexpressed in the majority of rectal cancers treated with radiotherapy and likely plays a role in local relapse. |
| Databáze: | OpenAIRE |
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