Plasma biomarker factors associated with neurodevelopmental outcomes in children with perinatal HIV infection and controlled viremia

Autor:	Michael J. Boivin, Jennifer Canniff, Mark J. Giganti, Patricia A. Sirois, Mark J. Abzug, Suad Kapetanovic, Allison L. Agwu, Jane C. Lindsey, Adriana Weinberg, Grace Montepiedra
Rok vydání:	2021
Předmět:	Male 0301 basic medicine Oncology medicine.medical_specialty Angiogenesis Immunology HIV Infections Viremia Impulsivity Complement factor B Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Internal medicine medicine Humans Immunology and Allergy 030212 general & internal medicine Child Retrospective Studies business.industry Retrospective cohort study Executive functions medicine.disease Vascular endothelial growth factor 030104 developmental biology Infectious Diseases chemistry Neurodevelopmental Disorders Child Preschool Biomarker (medicine) Female medicine.symptom business Biomarkers
Zdroj:	AIDS
ISSN:	1473-5571 0269-9370
Popis:	OBJECTIVE We examined relationships between plasma biomarkers and neurodevelopment in children from sub-Saharan Africa with perinatal HIV (PHIV) with controlled viremia on antiretroviral therapy (ART). DESIGN Longitudinal retrospective cohort study of children with controlled blood HIV replication. METHODS Children (N = 213; 57% girls) started ART at less than 3 years of age, had neurodevelopmental assessments (cognition, attention/impulsivity, motor proficiency, global executive functions) at 5-11 years, and achieved controlled viremia (HIV-1 RNA
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0408b5c840409b3bbd1021e0c8494ba4 https://doi.org/10.1097/qad.0000000000002862 Zobrazit plný text záznamu