Box–Behnken design directed optimization for sensitivity assessment of anti-platelet drugs
| Autor: | Amisha Vora, Vivek V Nalawade |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Ticlopidine Chemistry Pharmaceutical Electrospray ionization Pharmaceutical Science 02 engineering and technology Mass spectrometry Sensitivity and Specificity 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Drug Discovery Sensitivity (control systems) Chromatography High Pressure Liquid Pharmacology Chromatography Chemistry Design of experiments Organic Chemistry 021001 nanoscience & nanotechnology Anti platelet Box–Behnken design Clopidogrel Models Chemical 0210 nano-technology Platelet Aggregation Inhibitors |
| Zdroj: | Drug Development and Industrial Pharmacy. 45:1515-1522 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.1080/03639045.2019.1634092 |
| Popis: | Optimization of electrospray ionization (ESI) parameters is routinely carried out by one factor at a time (OFAT) or auto-tune software (ATS). Design of experiments (DOE) approach has been reported to be an excellent alternative to OFAT or ATS. Box-Behnken Design (BBD) was successfully used to optimize ESI parameters like nebulizing gas flow rate, desolvation line temperature, heat block temperature, and drying gas flow rate for [M + H] |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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