The risk of coronary artery disease after heart transplantation is increased in patients receiving low-dose cyclosporine, regardless of blood cyclosporine levels
| Autor: | Amando Gamba, Giuseppe Corbetta, Michele Senni, Filippo Mamprin, Roberto Ferrara, Paolo Ferrazzi, Gianni Troise, Roberto Fiocchi |
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| Přispěvatelé: | Gamba, A, Mamprin, F, Fiocchi, R, Senni, M, Troise, G, Ferrazzi, P, Ferrara, R, Corbetta, G |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Adolescent medicine.medical_treatment Coronary Disease Coronary artery disease Long-term Risk Factors Internal medicine Humans Medicine Risk factor Survival rate Aged Retrospective Studies Heart transplantation Dose-Response Relationship Drug business.industry Maintenance dose Incidence Incidence (epidemiology) Retrospective cohort study Articles General Medicine Middle Aged medicine.disease Surgery Survival Rate Transplantation Cyclosporine Cardiology Heart Transplantation Female Heart transplant Blood cyclosporine level Cardiology and Cardiovascular Medicine business Immunosuppressive Agents Follow-Up Studies |
| Zdroj: | Clinical Cardiology. 20:767-772 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.4960200911 |
| Popis: | Background: Coronary artery disease (CAD) of allografted hearts is the main cause of late mortality after cardiac transplant, but its etiology is still undetermined. Hypothesis: This study was undertaken to evaluate the relevance of several risk factors, including cyclosporine (CsA) dose and blood CsA levels, to the incidence of CAD.Methods: In 163 heart transplants performed between November 1985 and August 1994 at our Institution, CAD was diagnosed by coronary angiography or at postmortem examination. Patients in whom postmortem examination or coronary angiography was not performed, as well as those 4 mg/kg/day, the 8.9 year probability of their remaining CAD free was 69% [confidence interval (CI) 50-87%] in comparison with 31% (CI 0-65%) in patients receiving a CsA dose(w) < 4 mg/kg/day.Conclusion: In our experience, a low CsA maintenance dose is the main risk factor for CAD, irrespective of blood CsA levels. |
| Databáze: | OpenAIRE |
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