Detection of herpes simplex virus (1 and 2), varicella-zoster virus, cytomegalovirus, human herpesvirus 6 and enterovirus in immunocompetent tunisian patients with acute neuromeningeal disorder
| Autor: | Berthe-Marie Imbert-Marcille, Saber Chebel, Céline Bressollette-Bodin, Abid Nabil Ben Salem, Hanen Boukoum, Mohamed Neji Guediche, Fouad Ben Romdane, Mahjoub Aouni, Imen Nahdi, M. Chakroun, Frih-Ayed Mahbouba, Saber Hammami |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Herpesvirus 3 Human Tunisia Adolescent Herpesvirus 2 Human Herpesvirus 6 Human viruses Cytomegalovirus Herpesvirus 1 Human medicine.disease_cause Virus Young Adult Meninges Virology Enterovirus Infections medicine Humans Meningitis Child Herpesviridae Aged Enterovirus Aged 80 and over biology Varicella zoster virus Infant virus diseases Aseptic meningitis Herpesviridae Infections Middle Aged biology.organism_classification medicine.disease Infectious Diseases Herpes simplex virus Child Preschool DNA Viral Immunology Etiology RNA Viral Female Human herpesvirus 6 |
| Zdroj: | Journal of Medical Virology. 84:282-289 |
| ISSN: | 0146-6615 |
| DOI: | 10.1002/jmv.23192 |
| Popis: | Enteroviruses (EVs) and human herpesviruses (HHVs) are involved frequently in acute neurological disorders of viral etiology. This study aimed to investigate the incidence of herpes simplex virus types-1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human enteroviruses (EVs) in cerebrospinal fluid (CSF) samples of Tunisian immunocompetent patients with neuromeningeal disorders. The patients had been hospitalized at the Fattouma Bourguiba University Hospital (Monastir, Tunisia) between September 2007 and June 2009. At least one viral genome was detected in 58 (46%) out of 126 CSF samples collected. Enterovirus was detected in 31 of the positive samples (53.4%), CMV in 20 (34.5%), HSV-1 in 3 (5.2%), HSV-2 in 6 (10.3%), VZV in 4 (6.9%), HHV-6 in 2 (3.4%). More than one viral genome was detected in seven CSF samples, including CMV DNA in six of the samples. The high frequency of enteroviral infections in aseptic meningitis was confirmed. The detection of CMV DNA only suggests a direct role of this virus in the etiology of acute neuromeningeal disorder. |
| Databáze: | OpenAIRE |
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