Involvement of the lateral habenula in fear memory
| Autor: | Chantal Mathis, Laura Durieux, Lucas Lecourtier, Monique Majchrzak, Victor Mathis, Marc–Antoine Muller, Rémy Schlichter, Karine Herbeaux, Alexandra Barbelivien, Sylvain Hugel |
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| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de neurosciences cognitives et adaptatives (LNCA) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
c-fos Histology [SDV]Life Sciences [q-bio] Conditioning Classical Stimulus (physiology) Motor Activity Amygdala Hippocampus Prefrontal cortex 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Memory medicine Animals 0501 psychology and cognitive sciences Rats Long-Evans Fear conditioning Freezing Reaction Cataleptic Lateral habenula ComputingMilieux_MISCELLANEOUS Habenula General Neuroscience 05 social sciences Information processing Context Cognition Fear Chemogenetic medicine.anatomical_structure Conditioning Anatomy Psychology Neuroscience Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery |
| Zdroj: | Brain Structure and Function Brain Structure and Function, Springer Verlag, 2020, 225 (7), pp.2029-2044. ⟨10.1007/s00429-020-02107-5⟩ |
| ISSN: | 1863-2653 1863-2661 |
| Popis: | International audience; Increasing evidence points to the engagement of the lateral habenula (LHb) in the selection of appropriate behavioral responses in aversive situations. However, very few data have been gathered with respect to its role in fear memory formation, especially in learning paradigms in which brain areas involved in cognitive processes like the hippocampus (HPC) and the medial prefrontal cortex (mPFC) are required. A paradigm of this sort is trace fear conditioning, in which an aversive event is preceded by a discrete stimulus, generally a tone, but without the close temporal contiguity allowing for their association based on amygdala-dependent information processing. In a first experiment, we analyzed cellular activations (c-Fos expression) induced by trace fear conditioning in subregions of the habenular complex, HPC, mPFC and amygdala using a factorial analysis to unravel functional networks through correlational analysis of data. This analysis suggested that distinct LHb subregions engaged in different aspects of conditioning, e.g. associative processes and onset of fear responses. In a second experiment, we performed chemogenetic LHb inactivation during the conditioning phase of the trace fear conditioning paradigm and subsequently assessed contextual and tone fear memories. Whereas LHb inactivation did not modify rat's behavior during conditioning, it induced contextual memory deficits and enhanced fear to the tone. These results demonstrate the involvement of the LHb in fear memory. They further suggest that the LHb is engaged in learning about threatening environments through the selection of relevant information predictive of a danger. |
| Databáze: | OpenAIRE |
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