Cytotoxic, anti-proliferative and antimicrobial furanoditerpenoids from Stuhlmania moavi
| Autor: | Ute Möllman, Josiah O. Odalo, Mayunga H.H. Nkunya, Isabel Sattler, Cosam C. Joseph, Corina Lange, Hans-Martin Dahse |
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| Rok vydání: | 2009 |
| Předmět: |
Antifungal
Antifungal Agents medicine.drug_class Stereochemistry Chemical structure Plant Science Horticulture Biology Biochemistry Magnoliopsida Mice Cell Line Tumor Neoplasms medicine Cytotoxic T cell Animals Humans Cytotoxicity Medicinal plants Molecular Biology Cell Proliferation Traditional medicine Plant Extracts General Medicine Anti proliferative Antimicrobial Antineoplastic Agents Phytogenic Anti-Bacterial Agents visual_art visual_art.visual_art_medium Bark Artemia Diterpenes Plant Structures Phytotherapy |
| Zdroj: | Phytochemistry. 70(17-18) |
| ISSN: | 1873-3700 |
| Popis: | The furanoditerpenoids voucapane, voucapane-6alpha,7alpha-diol, voucapane-18,19-diol and 18-hydroxyvoucapan-19-al were isolated from the cytotoxic stem and root bark extracts of Stuhlmaniamoavi Verdc. (Ceasalpiniaceae) and their structures established based on analysis of spectroscopic data. The compounds exhibited anti-proliferative, cytotoxic, antibacterial and antifungal activities, 18-hydroxyvoucapan-19-al showing the highest anti-proliferative and cytotoxic properties. Voucapane-18,19-diol was only mildly active but the activity was enhanced for its 18,19-di-(4-methyl)-benzenesulphonate. Some of these results thus corroborate the traditional medicinal uses of the crude extracts for the treatment of skin infections. |
| Databáze: | OpenAIRE |
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