Testing the critical window of estradiol replacement on gene expression of vasopressin, oxytocin, and their receptors, in the hypothalamus of aging female rats
| Autor: | Weiling Yin, Christina Depena, Alexandra N. Garcia, Andrea C. Gore |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
endocrine system Aging Vasopressin medicine.medical_specialty Time Factors Vasopressins Ovariectomy Hypothalamus Biology Oxytocin Biochemistry Article Supraoptic nucleus 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Animals Molecular Biology Regulation of gene expression Estradiol Estrogens medicine.disease Oxytocin receptor Rats Menopause 030104 developmental biology Gene Expression Regulation Ovariectomized rat Female Supraoptic Nucleus hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Paraventricular Hypothalamic Nucleus medicine.drug |
| Zdroj: | Molecular and Cellular Endocrinology. 419:102-112 |
| ISSN: | 0303-7207 |
| Popis: | The current study tested the "critical window" hypothesis of menopause that postulates that the timing and duration of hormone treatment determine their potential outcomes. Our focus was genes in the rat hypothalamus involved in social and affiliative behaviors that change with aging and/or estradiol (E2): Avp, Avpr1a, Oxt, Oxtr, and Esr2 in the paraventricular nucleus (PVN) and supraoptic nucleus (SON). Rats were reproductively mature or aging adults, ovariectomized, given E2 or vehicle treatment of different durations, with or without a post-ovariectomy delay. Our hypothesis was that age-related changes in gene expression are mitigated by E2 treatments. Contrary to this, PVN Oxtr increased with E2, and Avpr1a increased with age. In the SON, Avpr1a increased with age, Oxtr with age and timing, and Avp was altered by duration. Thus, chronological age and E2 have independent actions on gene expression, with the "critical window" hypothesis supported by the observed timing and duration effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect