Effects of fetuin-A with diverse functions and multiple mechanisms on human health
| Autor: | Mehmet Arif Icer, Hilal Yildiran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
030213 general clinical medicine
alpha-2-HS-Glycoprotein Clinical Biochemistry 030204 cardiovascular system & hematology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Neoplasms Diabetes Mellitus medicine Humans Obesity Receptor Cell Proliferation Kinase Akt/PKB signaling pathway Chemistry Autophosphorylation Calcinosis General Medicine medicine.disease Fetuin Cell biology Cardiomyopathies Tyrosine kinase Signal Transduction Calcification |
| Popis: | Fetuin-A (Alfa 2-Heremans-Schmid) is a glycoprotein that is mainly synthesized by hepatocytes and then released into the bloodstream. While fetuin-A, a multifunctional protein, has inhibitory effects on health in the processes of calcification, mineralization, coronary artery calcification (CAC), and kidney stone formation by various mechanisms, it has such stimulatory effects as obesity, diabetes, and tumor progression processes. Fetuin-A produces these effects on the organism mainly by playing a role in the secretion levels of some inflammatory cytokines and exosomes, preventing unwanted calcification, inhibiting the autophosphorylation of tyrosine kinase, suppressing the release of adiponectin and peroxisome proliferator-activated receptor-gamma (PPAR gamma), activating the toll-like receptor 4 (TLR-4), triggering the phosphatidylinositol 3 (PI3) kinase/Akt signaling pathway and cell proliferation, and mimicking the transforming growth factor-beta (TGF-beta) receptor. In the present review, fetuinA was examined in a wide perspective from the structure and release of fetuin-A to its effects on health. |
| Databáze: | OpenAIRE |
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