Altered Intra- and Inter-regional Functional Connectivity of the Anterior Cingulate Gyrus in Patients With Tremor-Dominant Parkinson’s Disease Complicated With Sleep Disorder
| Autor: | Xinjie Chen, Xiaoyan Hou, Xiaodong Luo, Sifan Zhou, Xian Liu, Bo Liu, Jun Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty Parkinson's disease Brain activity and meditation Cognitive Neuroscience lcsh:RC321-571 Anterior cingulate gyrus Pittsburgh Sleep Quality Index Correlation 03 medical and health sciences 0302 clinical medicine Internal medicine medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research sleep disorder Sleep disorder business.industry Functional connectivity functional connectivity tremor-dominant Parkinson’s disease medicine.disease anterior cingulate gyrus Straight gyrus 030104 developmental biology Cardiology regional homogeneity business 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Frontiers in Aging Neuroscience, Vol 11 (2019) Frontiers in Aging Neuroscience |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2019.00319/full |
| Popis: | Objective: To investigate changes in brain function at the regional and whole-brain levels in patients with tremor-dominant Parkinson's disease (TDPD) complicated by sleep disorder (SD) by regional homogeneity (ReHo) and functional connectivity (FC) analysis of whole-brain resting-state functional magnetic resonance images. Materials and Methods: ReHo and seed-based FC analyses were conducted among 32 patients with TDPD and SD (TDPD-SD), 24 with TDPD and no SD (TDPD-NSD), and 23 healthy controls (HCs) to assess spontaneous brain activity and network-level brain function. Correlation analyses were used to examine the associations between brain activity and the clinical data. Results: Anterior cingulate gyrus (ACC) ReHo values differed significantly among the groups. ACC ReHo values were increased in TDPD-SD vs. HC and TDPD-SD vs. TDPD-NSD. ACC ReHo values were reduced in TDPD-NSD vs. HC. TDPD-SD ReHo values were positively correlated with Pittsburgh Sleep Quality Index (PSQI) scores (r = 0.41, p = 0.020) but negatively correlated with Parkinson's Disease Sleep Scale (PDSS) scores (r = -0.38, p = 0.030). FC analysis using ACC as a mask showed that FC of the left olfactory cortex (L-OC), right straight gyrus (R-SG), right superior parietal gyrus (R-SPG), and right precuneus differed significantly among the groups. FC values between R-SG and ACC were significantly lower in TDPD-SD than in TDPD-NSD, while the FC of L-OC and R-OC with ACC was significantly lower in TDPD-SD than in HC. FC between ACC and L-OC, R-SPG, and the right precuneus was lower in TDPD-NSD than in HC. There was no correlation between the FC values and other clinical data in any of the groups. Conclusion: Localized abnormal activity in TDPD-SD was chiefly triggered by ACC. The change in the ReHo of ACC is closely related to the severity of TDPD-associated SD, revealing the role of this region as a regulator of the sleep mechanism in TDPD. Significant abnormal FC was found between R-SG and ACC in TDPD-SD but was not shown to correlate with clinical data. |
| Databáze: | OpenAIRE |
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