Oxidative Stress and Genotoxicity in Pterygium: A Systemic Investigation
| Autor: | Yasin Ozdemir, Ibrahim Toprak, Emine Kilic-Toprak, Sadettin Çalışkan, Fatih Altıntaş, Onder Demirtas, Vural Kucukatay |
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| Rok vydání: | 2019 |
| Předmět: |
Male
antioxidant tantalum Lymphocyte Pterygium medicine.disease_cause Gastroenterology Antioxidants middle aged oxidative stress Medicine oxidizing agent genetics Lymphocytes Prospective Studies Prospective cohort study comparative study clinical article adult Middle Aged Comet DNA Oxidative stress female medicine.anatomical_structure priority journal Female Comet Assay Oxidation-Reduction prospective study medicine.medical_specialty DNA damage lymphocyte Article thallium comet assay Internal medicine cross-sectional study Humans controlled study titanium human business.industry genotoxicity Case-control study Antioxidants/metabolism Case-Control Studies Cross-Sectional Studies DNA Damage/*genetics Lymphocytes/pathology Oxidative Stress/*physiology Pterygium/*genetics/*metabolism case control study tail intensity medicine.disease eye diseases Comet assay Oxidative Stress Ophthalmology physiology pathology sense organs business metabolism oxidation reduction reaction Genotoxicity DNA Damage |
| Zdroj: | Eye & Contact Lens: Science & Clinical Practice. 45:399-404 |
| ISSN: | 1542-2321 |
| DOI: | 10.1097/icl.0000000000000620 |
| Popis: | Objectives: To perform a systemic investigation on oxidative stress and DNA damage in patients with primary pterygium. Methods: This prospective cross-sectional study included 32 patients with primary pterygium (60.1 +/- 2.0 years of age) and 33 age- and sex-matched (58.8 +/- 2.2 years of age) control subjects (P>0.05). A commercial kit was used for measuring serum total oxidant status (TOS) and total antioxidant status (TAS). The comet assay was performed after lymphocyte isolation from venous blood to quantitate DNA damage. Tail length (TL), tail intensity (TI), and tail moment (TM) were used for statistical analysis as parameters of DNA damage. Results: In the pterygium group, TOS and TAS were significantly higher when compared with those of the control group (P=0.019 and P=0.005, respectively). In terms of DNA damage, patients with pterygium had higher TL, TI, and TM than in the control subjects (P |
| Databáze: | OpenAIRE |
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