Lung Microbiome in Asthma: Current Perspectives
| Autor: | Konstantinos Loverdos, Evangelos Giamarellos, Georgios Bellos, Antonia Koutsoukou, Matteo Pecchiari, Nikoletta Rovina, Louiza Kokolatou, Nikolaos Koulouris, Ioannis Vasileiadis |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Lung microbiome business.industry pathogenesis Human microbiome microbiome Asthma treatment Bacteriome Review General Medicine asthma medicine.disease immune responses respiratory tract diseases 3. Good health 03 medical and health sciences 0302 clinical medicine 030228 respiratory system inflammation Immunology medicine Microbiome business 030304 developmental biology Asthma |
| Zdroj: | Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm8111967 |
| Popis: | A growing body of evidence implicates the human microbiome as a potentially influential player actively engaged in shaping the pathogenetic processes underlying the endotypes and phenotypes of chronic respiratory diseases, particularly of the airways. In this article, we specifically review current evidence on the characteristics of lung microbiome, and specifically the bacteriome, the modes of interaction between lung microbiota and host immune system, the role of the “lung–gut axis”, and the functional effects thereof on asthma pathogenesis. We also attempt to explore the possibilities of therapeutic manipulation of the microbiome, aiming at the establishment of asthma prevention strategies and the optimization of asthma treatment. |
| Databáze: | OpenAIRE |
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