Modeling the evolution of the human mitochondrial genome
| Autor: | R.H. Ward, Ron Lundstrom, Simon Tavaré |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Statistics and Probability
Mutation rate Mitochondrial DNA Population Population genetics Biology Human mitochondrial genetics DNA Mitochondrial General Biochemistry Genetics and Molecular Biology Coalescent theory Humans education Genetics education.field_of_study Models Statistical General Immunology and Microbiology Models Genetic Genome Human Applied Mathematics General Medicine Biological Evolution Evolutionary biology Modeling and Simulation Mutation (genetic algorithm) Mutation Human genome General Agricultural and Biological Sciences |
| Zdroj: | Mathematical biosciences. 112(2) |
| ISSN: | 0025-5564 |
| Popis: | Mitochondrial DNA data have been used extensively to study evolution and early human origins. These applications require estimates of the rate at which nucleotide substitutions occur in the DNA sequence. We consider the problem of estimating substitution rates in the presence of site-to-site rate variation. A coalescent model is presented that allows for different substitution rates for purines and pyrimidines, as well as more detailed models that allow fast and slow rates within each of the purine and pyrimidine classes. A method for estimating such rates is presented. Even for these simple models of site heterogeneity, there are, typically, insufficient data to obtain reliable estimates of site-specific substitution rates. However, estimates of the average rate across all sites appear to be relatively stable even in the presence of site heterogeneity. Simulations of models with site-to-site variation in mutation rate show that hypervariable sites can produce peaks in the pairwise difference curves that have previously been attributed to population dynamics. |
| Databáze: | OpenAIRE |
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