Exposure to air pollutants and the gut microbiota: a potential link between exposure, obesity, and type 2 diabetes
| Autor: | Laura E. Wild, Tanya L. Alderete, Noopur N. Naik, Maximillian J. Bailey, William B. Patterson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) obesity Air pollution exposure air pollution Review Type 2 diabetes RC799-869 Gut flora Microbiology digestive system 03 medical and health sciences 0302 clinical medicine Air pollutants Risk Factors medicine Animals Humans Nitrogen oxides Inflammation Air Pollutants Bacteria biology Human studies gut microbiota Gastroenterology Diseases of the digestive system. Gastroenterology biology.organism_classification medicine.disease gut health Obesity Gastrointestinal Microbiome Gastrointestinal Tract 030104 developmental biology Infectious Diseases Increased risk Diabetes Mellitus Type 2 Models Animal Immunology Particulate Matter 030211 gastroenterology & hepatology type 2 diabetes |
| Zdroj: | Gut Microbes, Vol 11, Iss 5, Pp 1188-1202 (2020) Gut Microbes |
| ISSN: | 1949-0984 1949-0976 |
| Popis: | Work has shown that increased exposure to air pollutants independently contributes to obesity and type 2 diabetes risk, yet the exact mechanisms underlying these associations have not been fully characterized. The current review summarizes recent findings regarding the impact of inhaled and ingested air pollutants on the gut microbiota. Animal and human studies provide evidence that air pollutants, such as particulate matter, nitrogen oxides, and ozone, have the potential to alter the gut microbiota. Further, studies suggest that such exposure-induced alterations to the gut microbiota may contribute to increased risk for obesity and type 2 diabetes through inflammatory pathways. Future work is needed to fully understand the complex interactions between air pollution, the gut microbiome, and human health. Additionally, advanced sequencing methods for gut microbiome research present unique opportunities to study the underlying pathways that link increased air pollution exposure with obesity and type 2 diabetes risk. |
| Databáze: | OpenAIRE |
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