The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy
| Autor: | Bram Ramaekers, Miranda E.M.C. Christianen, Ivo Beetz, Janneke P.C. Grutters, Madelon Pijls-Johannesma, Jos M.A. de Jong, Johannes A. Langendijk, Piet van den Ende, Ruud Houben, Philippe Lambin, Manuela A. Joore |
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| Přispěvatelé: | Health Services Research, MUMC+: KIO Kemta (9), Radiotherapie, RS: CAPHRI School for Public Health and Primary Care, RS: GROW - School for Oncology and Reproduction, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Quality of life medicine.medical_specialty Cancer Research Visual analogue scale Cross-sectional study Health Status medicine.medical_treatment Xerostomia Young Adult Internal medicine otorhinolaryngologic diseases Humans Medicine Young adult Radiation Injuries Head and neck cancer Aged Aged 80 and over UTILITY Radiotherapy business.industry Dysphagia Middle Aged medicine.disease humanities Deglutition Surgery Radiation therapy NORMS Cross-Sectional Studies Treatment Outcome Oncology Head and Neck Neoplasms Population study Female medicine.symptom Oral Surgery Deglutition Disorders Salivation business Attitude to Health |
| Zdroj: | Oral Oncology, 47(8), 768-774. Elsevier Science Oral Oncology, 47(8), 768-774. ELSEVIER SCIENCE BV |
| ISSN: | 1368-8375 |
| Popis: | To examine the impact of late treatment-related xerostomia and dysphagia on health-related quality of life (HRQOL) in head and neck cancer (HNC) patients after radiotherapy. A multi-center cross-sectional survey was performed. Patients with a follow-up of at least 6 months after curative radiotherapy, without evidence of recurrent disease were eligible for inclusion. The Euroqol-5D questionnaire (EQ-5D) was filled out and toxicity was scored and converted to the RTOG scale. The EQ-5D measures generic HRQOL in terms of utility and visual analogue scale (VAS) scores. Missing data on the EQ-5D were imputed using multiple imputation. HRQOL was compared between subgroups of patients with and without toxicity. Subsequently, the impact of xerostomia and dysphagia on HRQOL was analyzed using multivariate regression analyses. Both analyses were performed separately for utility scores and VAS scores. The study population was composed of 396 HNC patients. The average utility and VAS scores were 0.85 (scale 0-1) and 75 (scale 0-100). Subgroups of patients with xerostomia and/or dysphagia showed statistically significantly lower utility and VAS scores (P = 0.000-0.022). The multivariate regression model showed that xerostomia and dysphagia were negative predictors of both utility and VAS scores. Other factors which influenced HRQOL in at least one of the two regression models were: sex, tumor location and the addition of surgery to radiotherapy. Xerostomia and dysphagia diminish generic HRQOL. Moreover dysphagia affects patients' HRQOL stronger than xerostomia. (C) 2011 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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