Livestock-Associated MRSA in Household Members of Pig Farmers: Transmission and Dynamics of Carriage, A Prospective Cohort Study

Autor: van Cleef, Brigitte A G L, van Benthem, Birgit H B, Verkade, Erwin J M, van Rijen, Miranda M L, Kluytmans-van den Bergh, Marjolein F Q, Graveland, Haitske, Bosch, Thijs, Verstappen, Koen M H W, Wagenaar, Jaap A, Bos, Marian E H, Heederik, Dick, Kluytmans, Jan A J W, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, LS Klinisch Onderzoek Wagenaar, LS IRAS EEPI GRA (Gezh.risico-analyse), dI&I I&I-4, Infection & Immunity
Přispěvatelé: Medical Microbiology and Infection Prevention, CCA - Immuno-pathogenesis, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, LS Klinisch Onderzoek Wagenaar, LS IRAS EEPI GRA (Gezh.risico-analyse), dI&I I&I-4, Infection & Immunity
Rok vydání: 2015
Předmět:
Methicillin-Resistant Staphylococcus aureus
Veterinary medicine
Livestock associated
Livestock
Swine
lcsh:Medicine
Oropharynx
Nose
medicine.disease_cause
Staphylococcal infections
Research Support
law.invention
law
Environmental health
medicine
Journal Article
Life Science
Animals
Humans
Prospective Studies
Prospective cohort study
lcsh:Science
Non-U.S. Gov't
Netherlands
Host Pathogen Interaction & Diagnostics
Multidisciplinary
Farmers
business.industry
Research Support
Non-U.S. Gov't
Bacteriologie
lcsh:R
Bacteriology
Bacteriology
Host Pathogen Interaction & Diagnostics
Staphylococcal Infections
biochemical phenomena
metabolism
and nutrition
medicine.disease
bacterial infections and mycoses
Methicillin-resistant Staphylococcus aureus
Host Pathogen Interactie & Diagnostiek
Carriage
Transmission (mechanics)
Bacteriologie
Host Pathogen Interactie & Diagnostiek
Carrier State
lcsh:Q
business
Cohort study
Research Article
Zdroj: PLoS ONE, 10(5):e0127190. Public Library of Science
PLoS ONE
PLoS ONE 10 (2015) 5
van Cleef, B A G L, van Benthem, B H B, Verkade, E J M, van Rijen, M M L, Kluytmans-van d Bergh, M, Graveland, H, Bosch, T, Verstappen, K M H W, Wagenaar, J A, Bos, M E H, Heederik, D & Kluytmans, J A J W 2015, ' Livestock-Associated MRSA in Household Members of Pig Farmers: Transmission and Dynamics of Carriage, A Prospective Cohort Study ', PLoS ONE, vol. 10, no. 5, e0127190 . https://doi.org/10.1371/journal.pone.0127190
PLoS ONE [E], 10(5). Public Library of Science
PLoS ONE, 10(5)
PLoS One, 10(5). Public Library of Science
PLoS ONE, Vol 10, Iss 5, p e0127190 (2015)
ISSN: 1932-6203
2010-2011
Popis: This prospective cohort study describes carriage of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in household members from 49 farrowing pig farms in the Netherlands (2010-2011). Of 171 household members, 4% were persistent MRSA nasal carriers, and the MRSA prevalence on any given sampling moment was 10% (range 7-11%). Working in the stables (of which 98% was MRSA-positive, prevalence ratio (PR) = 2.11 per 10 hours), working with sows (PR=1.97), and living with an MRSA-positive pig farmer (PR=4.63) were significant determinants for MRSA carriage. Significant protective factors w000354917300100ere carriage of methicillin-susceptible Staphylococcus aureus (MSSA) (PR=0.50), and wearing a facemask when working in the stables (37% decreased prevalence). All MRSA strains during the study period were known livestock-associated types. The bacteriophage φ3 was not found in household members. Transmission from pigs and the environment appeared to be important determinants; human-to-human transmission could not sufficiently be differentiated. Wearing a facemask when working in the stables and carriage of MSSA are potential interventional targets.
Databáze: OpenAIRE
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