Improvement of hydrogelation abilities and handling of photocurable gelatin-based crosslinking materials
| Autor: | Chie Fukaya, Yasuo Hosaka, Taneaki Nakagawa, Sadao Omata, Yasuhide Nakayama, Ayaka Ishikawa, Yoshinobu Murayama |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
food.ingredient
Materials science Photochemistry Biomedical Engineering Biocompatible Materials Gelatin Coupling reaction Biomaterials Dental Materials chemistry.chemical_compound food Elastic Modulus Materials Testing Polymer chemistry Polyamines Humans Regeneration Molecule Elastic modulus Molecular Structure Eosin Molecular mass Hydrogels Microporous material Molecular Weight Cross-Linking Reagents Chemical engineering chemistry Self-healing hydrogels Eosine Yellowish-(YS) |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials. :329-336 |
| ISSN: | 1552-4981 1552-4973 |
| DOI: | 10.1002/jbm.b.31406 |
| Popis: | Three types of eosin-derivatized gelatins (eosin-gelatins) with different molecular weights (M(w)) of ca. 15 kDa (low-molecular-weight eosin-gelatin, LEG), ca. 30 kDa (medium-molecular-weight eosin-gelatin, MEG), and ca. 95 kDa (high-molecular-weight eosin-gelatin, HEG) were prepared. All the eosin-gelatins except for HEG dissolved completely in water at 37 degrees C within several hours even at high concentrations of 35 or 40 wt % along with polyamine (poly(N,N-dimethylaminopropylacrylamide)) to produce photo-crosslinkable materials. The materials had appropriate viscosity for in situ molding at 37 degrees C and could be handled as a liquid at low temperatures of up to 25 degrees C. Upon photoirradiation for several tens of seconds, the materials were converted almost completely to hydrogels in the desired form with a microporous network structure by the radical coupling reaction. The mechanical strength of the produced hydrogels could be controlled by selecting a particular molecular weight or concentration of eosin-gelatins. The hydrogels obtained from LEG (40 wt %) or MEG (35 wt %) had elasticity similar to that of goat periodontal tissue. The handling of the photo-crosslinkable materials at room temperature and their photogelation ability were drastically improved by reducing the M(w) of eosin-gelatin. The potential usefulness of the photo-crosslinkable materials to periodontal regeneration has been discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text