Time‐Dependent Changes in the Structure of Calcified Fibrocartilage in the Rat Achilles Tendon–Bone Interface With Sciatic Denervation
| Autor: | Mineo Oyama, Noriaki Yamamoto, Hiroyuki Tamaki, Hideaki Onishi, Hideaki E. Takahashi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Time Factors Histology 030209 endocrinology & metabolism Hard tissue Achilles Tendon Weight-Bearing Random Allocation 03 medical and health sciences Calcification Physiologic 0302 clinical medicine Collagen fiber Animals Medicine Rats Wistar Muscle Skeletal Ecology Evolution Behavior and Systematics Denervation Achilles tendon business.industry Fibrocartilage Anatomy Enthesis Sciatic Nerve Rats Calcaneus 030104 developmental biology medicine.anatomical_structure Collagen fiber bundle business Biotechnology |
| Zdroj: | The Anatomical Record. 300:2166-2174 |
| ISSN: | 1932-8494 1932-8486 |
| DOI: | 10.1002/ar.23684 |
| Popis: | The enthesis transmits a physiological load from soft to hard tissue via fibrocartilage. The histological alterations induced by this physiological loading remain unclear. This study was performed to examine the histomorphological alterations in the collagen fiber bundle alignment and depth of collagen interdigitation between the calcified fibrocartilage and the bone. We examined the Achilles enthesis of rats with sciatic denervation to explore the mechanical effects of structural changes in the enthesis. The parallelism of the collagen fiber bundles was significantly reduced 8 weeks after denervation. However, the depth of collagen interdigitation significantly increased at 2 and 4 weeks after denervation and then significantly decreased 8 weeks after denervation. In conclusion, a lack of muscle loading induced structural alterations in the distal calcified fibrocartilage. These findings suggest that while structural changes in the enthesis are necessary for the development of physiological loading, structural deformities are required in the long term. Anat Rec, 300:2166-2174, 2017. © 2017 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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