High Pregnancy, Cord Blood, and Infant Vitamin D Concentrations May Predict Slower Infant Growth
| Autor: | Elisa Holmlund-Suila, Timo Hytinantti, Otto Helve, Helena Hauta-alus, Heli Viljakainen, Sture Andersson, Saara Valkama, Eero Kajantie, Jenni Rosendahl, Outi Mäkitie, Maria Enlund-Cerullo |
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| Přispěvatelé: | Children's Hospital, Clinicum, University of Helsinki, HUS Children and Adolescents, Lastentautien yksikkö, Department of Food and Nutrition |
| Rok vydání: | 2018 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Umbilical cord Child Development 0302 clinical medicine Endocrinology Pregnancy 3123 Gynaecology and paediatrics Medicine 030212 general & internal medicine Vitamin D D INTERVENTION Finland 25-HYDROXYVITAMIN D CONCENTRATION Outcome measures ASSOCIATION Fetal Blood Prognosis medicine.anatomical_structure Cord blood Female Adult D SUPPLEMENTATION medicine.medical_specialty Mothers 030209 endocrinology & metabolism Context (language use) D DEFICIENCY 03 medical and health sciences AGE Internal medicine Vitamin D and neurology Humans HEALTHY FETAL Fetus business.industry Body Weight Biochemistry (medical) Infant Newborn Infant medicine.disease PREVENTION Body Height Infant length Pregnancy Trimester First FOLLOW-UP business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 104:397-407 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2018-00602 |
| Popis: | Context The relationship of maternal and infant 25-hydroxyvitamin D concentration [25(OH)D] with infant growth is unclear. Objective Our objective was to explore whether 25(OH)D in pregnancy, umbilical cord blood (UCB), or in infancy was associated with infant growth. Design This study involved 798 healthy infants and their mothers in Finland. We assessed 25(OH)D during pregnancy, from UCB at birth, and from the infant at the age of 12 months. Main Outcome Measures Infant length, weight, length-adjusted weight, and head circumference at 6 and 12 months and midupper-arm circumference at 12 months. Results Of the mothers and infants, 96% and 99% were vitamin D sufficient [25(OH)D ≥50 nmol/L], respectively. Mothers with pregnancy 25(OH)D >125 nmol/L had the shortest, lightest (in weight), and thinnest (in length-adjusted weight) infants at 6 months (P for all < 0.05). For each 10 nmol/L higher UCB 25(OH)D, the infants were 0.03 SD score (SDS) shorter at 6 months (95% CI −0.05 to −0.01), adjusted for birth size, infant 25(OH)D, and parental height. Higher UCB 25(OH)D associated with smaller head circumference at 6 and 12 months (P for all 125 nmol/L had the thinnest infants at 12 months (P = 0.021). For each 10 nmol/L higher infant 25(OH)D, the infants were 0.03 SDS lighter (−0.05 to −0.01) and 0.03 SDS thinner (−0.05 to 0.00) at 12 months. Conclusions Our results suggest that high pregnancy, cord blood, and infant vitamin D concentration may have disadvantageous effects on infant growth. |
| Databáze: | OpenAIRE |
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